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Updated: Dec 15, 2025
Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model
Published on: August 11, 2023
Microembolic Signals Detected by Transcranial Doppler Predict Future Stroke and Poor Outcomes
Alvin S Das1,2, Robert W Regenhardt2, Sarah LaRose1
1Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Background And Purpose:
Although transcranial Doppler detects microembolic signals (MES) in numerous settings, the practical significance of such findings remains unclear.
Methods:
Clinical information from ischemic stroke or transient ischemic attack patients (n = 248) who underwent embolic monitoring from January 2015 to December 2018 was obtained.
Results:
MES were found in 15% of studies and ischemic recurrence was seen in 11% of patients (over 7 ± 6 days). Patients with MES had more lacunes than those without MES (1 ± 3 vs. 1 ± 2, P = .016), were more likely to have ischemic recurrence (37% vs. 6%, P < .001), undergo a future revascularization procedure (26% vs. 10%, P = .005), have a longer length of stay (9 vs. 4 days, P = .043), and have worse functional disability at discharge (modified Rankin Scale 3-6, 66% vs. 34%, P < .001). After controlling for several relevant cofactors, patients with MES were more likely to have ischemic recurrence (HR 4.90, 95% CI 2.16-11.09, P < .001), worse functional disability (OR 3.31, 95% CI 1.22-8.99, P = .019), and longer length of stays (β = .202, P < .001).
Conclusions:
MES may help to risk stratify patients as their presence is associated with ischemic recurrence and worse outcomes.
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