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Related Experiment Video

Updated: Dec 15, 2025

Manipulation of Single Neural Stem Cells and Neurons in Brain Slices using Robotic Microinjection
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Manipulation of Single Neural Stem Cells and Neurons in Brain Slices using Robotic Microinjection

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Low-Invasive Cell Injection based on Rotational Microrobot.

Haojian Lu1, Yuanyuan Yang1, Xudong Lin1

  • 1Department of Biomedical Engineering, City University of Hong Kong, Hong Kong SAR, 999077, China.

Advanced Biosystems
|July 11, 2020
PubMed
Summary
This summary is machine-generated.

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A new robotic system uses homocentric rotation for microinjections, significantly reducing cell damage and penetration force. This low-invasive technique improves cell injection accuracy and efficiency for biomedical applications.

Area of Science:

  • Biomedical Engineering
  • Cell Biology
  • Robotics

Background:

  • Conventional microinjection methods face limitations in minimizing cell damage during penetration.
  • Existing techniques, such as micropipette tip optimization and vision-based systems, are nearing their performance limits.
  • There is a growing need for more accurate, efficient, and less invasive cell injection technologies.

Purpose of the Study:

  • To design and implement a novel robotic-aided rotatory microinjection system.
  • To reduce cell deformation and penetration force during microinjection procedures.
  • To overcome the limitations of traditional microinjection techniques.

Main Methods:

  • Development of a robotic system integrating homocentric rotation technology.
Keywords:
cell injectionlow invasiverobotic aided

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  • Utilizing an ultra-precise manipulation system with multiple degrees of freedom.
  • Systematic testing and comparison with traditional cell injection techniques using zebrafish embryos.

    • Main Results:

    • The rotatory microinjection system significantly diminishes cell damage.
    • Penetration deformation and force were reduced by up to 30% compared to traditional methods.
    • The system demonstrates improved accuracy and efficiency in cell injections.

    Conclusions:

    • The robotic-aided rotatory microinjection system offers a breakthrough in low-invasive cell injection.
    • This technology surpasses the performance limits of current microinjection techniques.
    • Potential applications include artificial fertilization, gene therapy, and other biomedical fields.