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Balancing Internal and External Validity Using Precis-2 and Re-Aim: Case Exemplars.

Pamela J Wright1, Bernardine M Pinto2, Cynthia F Corbett1

  • 1College of Nursing, Advancing Chronic Care through Research and Innovation Center (ACORN Center), University of South Carolina, Columbia, SC, USA.

Western Journal of Nursing Research
|July 11, 2020
PubMed
Summary
This summary is machine-generated.

Accelerating clinical practice changes requires balancing research validity. Using tools like PRECIS-2 and RE-AIM in study design can bridge the gap between scientific evidence and patient care.

Keywords:
knowledge translationpragmatic researchrandomized controlled trialresearch design

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Area of Science:

  • Health Services Research
  • Clinical Trials Methodology
  • Knowledge Translation Science

Background:

  • Significant annual investment in clinical trials by the National Institutes of Health ($3-$4 billion).
  • A substantial delay (average 17 years) exists between research evidence generation and its implementation into clinical practice.
  • The need for study designs that optimize both external and internal validity to enhance knowledge translation.

Purpose of the Study:

  • To evaluate two randomized controlled trials (RCTs) along the effectiveness-efficacy continuum.
  • To assess the utility of the PRagmatic Explanatory Continuum Indicator Summary (PRECIS-2) tool.
  • To examine the applicability of the Research Effectiveness Adoption Implementation Maintenance (RE-AIM) model.

Main Methods:

  • Case study approach analyzing two RCTs.
  • Application of the PRECIS-2 framework to assess trial design characteristics.
  • Utilizing the RE-AIM model to evaluate potential for real-world impact.
  • Focus on the effectiveness-efficacy continuum in research design.

Main Results:

  • The study provided insights into strategies for achieving a better balance in research design.
  • Evaluation highlighted how study design choices influence the translation of research findings.
  • Demonstrated the potential of PRECIS-2 and RE-AIM in guiding research planning.

Conclusions:

  • Strategic use of research design tools can accelerate knowledge translation.
  • Balancing internal and external validity is crucial for bridging the research-practice gap.
  • Implementing tools like PRECIS-2 and RE-AIM may expedite the integration of scientific evidence into clinical practice.