Related Experiment Video
Updated: Dec 15, 2025
13:10
Use of Alu Element Containing Minigenes to Analyze Circular RNAs
Published on: March 10, 2020
7.6K
Circular RNA in gastric cancer
Xue-Wei Li1, Wen-Hui Yang2, Jun Xu3
1Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan, Shanxi 030001, China.
Chinese Medical Journal
|July 11, 2020
Summary
Circular RNAs (circRNAs) show promise as biomarkers for early gastric cancer (GC) detection. Their role in tumor development offers new avenues for GC diagnosis and treatment strategies.
Area of Science:
- Molecular Biology
- Oncology
- Biochemistry
Background:
- Gastric cancer (GC) is a leading cause of cancer death with poor prognosis.
- Current early-stage GC screening methods are lacking in simplicity and effectiveness.
- Circular RNAs (circRNAs) are increasingly recognized for their roles in tumorigenesis.
Purpose of the Study:
- To review the structure and function of circRNAs.
- To summarize current research on circRNAs in gastric cancer.
- To discuss the diagnostic potential of circRNAs for GC.
Main Methods:
- Literature review of studies on circRNA structure, function, and role in GC.
- Analysis of data supporting circRNA involvement in cancer development.
- Evaluation of circRNA characteristics for diagnostic biomarker potential.
Main Results:
- CircRNAs possess unique structural specificity and biological stability.
- CircRNAs are implicated in key GC processes including proliferation, invasion, metastasis, and apoptosis.
- Emerging evidence suggests circRNAs as potential biomarkers for tumor diagnosis.
Conclusions:
- CircRNAs play a significant role in the development of gastric cancer.
- The stability and specificity of circRNAs make them promising diagnostic biomarkers for GC.
- Further research into circRNAs may lead to novel diagnostic and therapeutic strategies for GC.
Related Concept Videos
01:03Rous Sarcoma Virus (RSV) and Cancer
5.9K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.9K
01:24Small GTPases - Ras and Rho
5.0K
Ras and Rho are small monomeric GTPases that act downstream of receptor tyrosine kinase (RTK) and regulate various cellular processes. These GTPases switch between active and inactive states by binding to guanine nucleotides.
Three regulatory proteins control their activity:
Three regulatory proteins control their activity:
5.0K
02:55The Nucleolus
10.0K
The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
10.0K
02:15Experimental RNAi
7.1K
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
7.1K
02:38The Ras Gene
6.9K
The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a...
Ras is a...
6.9K
02:53Ribosomal RNA Synthesis
14.3K
Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
14.3K