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Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Related Experiment Video

Updated: Dec 15, 2025

Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma

Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma

Published on: March 13, 2013

Desmoplastic Melanoma as a Diagnostic Pitfall.

Ilkin Zindanci, Ebru Zemheri, Tugba Kevser Uzuncakmak

Acta Dermatovenerologica Croatica : ADC

|July 12, 2020

Summary

Desmoplastic melanoma (DM) is a rare skin cancer that can mimic benign lesions. Early dermoscopic detection of atypical vascular structures and pigment patterns aids in diagnosing this rare melanoma subtype.

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Last Updated: Dec 15, 2025

Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma

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Published on: March 13, 2013

A 3D Organotypic Melanoma Spheroid Skin Model

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A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

Area of Science:

Dermatology
Oncology
Pathology

Background:

Desmoplastic melanoma (DM) is a rare, often amelanotic, subtype of melanoma.
It typically presents as a firm, discoid lesion on sun-exposed areas in elderly patients.
DM can clinically mimic various benign and malignant skin conditions, complicating diagnosis.

Observation:

A 60-year-old male presented with a year-long history of an asymptomatic, erythematous plaque.
Dermoscopy revealed atypical vascular structures, milky-red areas, and atypical pigment network.
Histopathology showed a dermal proliferation of atypical spindle cells with positive S-100 and HMB45 staining.

Findings:

The patient was diagnosed with desmoplastic melanoma, nodular subtype, with a Breslow thickness of 4 mm.
Complete excision with clear margins was performed.
Sentinel lymph node biopsy and systemic imaging showed no metastases, with a 3-year disease-free follow-up.

Implications:

This case highlights the importance of considering desmoplastic melanoma in the differential diagnosis of unusual pink tumoral lesions.
Dermoscopic features, including atypical vascular patterns, can aid in early detection.
Prompt diagnosis and treatment are crucial for managing this rare melanoma subtype.