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Updated: Dec 15, 2025

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Coexisting central and obstructive sleep apnea and mild diurnal hypoventilation associated with unilateral
Sameh Msaad1, Amina Kotti1, Hela Zouari Gdoura2
1Department of pneumology, Hédi Chaker University Hospital of Sfax, University of Sfax, Km 0.5, Al Ain street, 3029 Sfax, Tunisia.
Abstract:
A 63-year old man was diagnosed with coexisting central (CSA) and obstructive (OSA) sleep apnea, crescendo-decrescendo (CD) periodic breathing (PB), frequent sustained desaturation hypoxemia events related to prolonged hypopnea and mild diurnal hypoventilation. Unilateral diaphragmatic dysfunction (DD) related to diabetic phrenic neuropathy was identified. Magnetic resonance imaging (MRI) scans of the head disclosed frontal-subcortical white matter (WM) lesions, while brainstem MRI found a small punctiform defect in the median area of the pons. Continuous positive airway pressure (CPAP) therapy was ineffective, while a one-month bi-level positive airway pressure (BIPAP) trial provided better outcomes.
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