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Osteocalcin, parathormone and hypercalciuria.

H Rico1, P Paramo, J Pérez del Molino

  • 1Internal Medicine Service, Hospital Universitario San Carlos, Universidad Complutense, Madrid, Spain.

European Urology
|January 1, 1988
PubMed
Summary
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Osteocalcin and parathormone levels do not effectively diagnose hypercalciuria. The calcium/creatinine ratio shows significant differences between renal and absorptive hypercalciuria, suggesting its utility in differentiating these conditions.

Area of Science:

  • Nephrology
  • Endocrinology
  • Metabolic Bone Disease

Background:

  • Osteocalcin synthesis is regulated by 1,25(OH)2D3, a vitamin D metabolite.
  • 1,25(OH)2D3 and parathormone are implicated in the etiology of hypercalciurias.
  • Hypercalciuria is a risk factor for renal lithiasis.

Purpose of the Study:

  • To evaluate osteocalcin and parathormone as diagnostic markers for hypercalciuria.
  • To compare urinary markers in patients with absorptive hypercalciuria (AH) and renal hypercalciuria (RH).

Main Methods:

  • Analysis of urinary osteocalcin, parathormone, 24-hour calciuria, calcium/creatinine (Ca/Cr), and hydroxyproline/creatinine ratios.
  • Study included 62 patients with renal lithiasis, comprising 18 with AH and 11 with RH.

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Main Results:

  • No significant differences were observed in osteocalcin or parathormone levels between AH and RH groups.
  • The Ca/Cr ratio was significantly higher in patients with RH (0.31 +/- 0.07 mg/mg) compared to AH (0.13 +/- 0.04 mg/mg) (p < 0.001).

Conclusions:

  • Osteocalcin and parathormone are not reliable indicators for diagnosing hypercalciuria.
  • The urinary Ca/Cr ratio is a valuable parameter for differentiating between renal and absorptive hypercalciuria.