Related Experiment Video
Updated: Dec 15, 2025
06:46
Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
Published on: December 14, 2020
3.2K
Reflux Hypersensitivity: How to Approach Diagnosis and Management
Pankaj Aggarwal1, Afrin N Kamal2
1University of Texas Health Science Center San Antonio, San Antonio, TX, USA.
Current Gastroenterology Reports
|July 12, 2020
Summary
Reflux hypersensitivity, defined by the Rome IV criteria, involves typical reflux symptoms without endoscopic disease. Neuromodulators show promise for future management, but more research is needed.
Area of Science:
- Gastroenterology
- Physiology
Background:
- Reflux hypersensitivity is characterized by typical reflux symptoms.
- Diagnosis requires the absence of endoscopic mucosal disease and pathologic gastroesophageal reflux.
Purpose of the Study:
- To review the definition and diagnostic criteria for reflux hypersensitivity.
- To discuss current and future management strategies.
Main Methods:
- Rome IV criteria redefined reflux hypersensitivity.
- Continuous pH monitoring aids diagnosis.
Main Results:
- Reflux hypersensitivity involves typical symptoms with positive symptom correlation to reflux.
- TPRV1 receptors are implicated in its pathophysiology.
- Neuromodulators (SSRIs, SNRIs, TCAs) show potential therapeutic efficacy.
Conclusions:
- Diagnosis is streamlined with Rome IV criteria and pH monitoring.
- While anti-secretory agents and neuromodulators show some efficacy, definitive therapy is lacking.
- Further research, including large-scale randomized controlled trials, is essential for pharmacotherapy.
Related Concept Videos
01:29Gastroesophageal Reflux Disease II: Clinical Features and Management
571
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
571
01:21Barrett Esophagus-II: Clinical Manifestations and Management
593
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
593
01:26Peptic Ulcer Disease IV: Management
320
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
320
01:29Gastroesophageal Reflux Disease I: Meaning and Pathophysiology
1.1K
Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
1.1K
01:26Esophageal Strictures-II: Clinical Features and Management
306
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
306
01:23Gastritis III: Clinical Manifestations and Management
972
The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
972