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Intracoronary Acetylcholine Provocation Testing for Assessment of Coronary Vasomotor Disorders
Published on: August 18, 2016
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Mental Health Status in Patients Undergoing Intracoronary Acetylcholine Provocation Test
Yuichi Saito1, Toshihiro Shoji2,3, Kazuya Tateishi2
1Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan. saitoyuichi1984@gmail.com.
Advances in Therapy
|July 12, 2020
Summary
Over 40% of patients undergoing vasospastic angina testing reported poor mental health, including anxiety and depression. However, this mental distress did not impact the acetylcholine provocation test results.
Area of Science:
- Cardiology
- Psychiatry
- Clinical Medicine
Background:
- Previous research links mental distress (anxiety, depression) to coronary vasoconstriction and myocardial ischemia.
- The mental health status of patients with suspected vasospastic angina remains unclear.
Purpose of the Study:
- To investigate the mental health status of patients undergoing diagnostic testing for vasospastic angina.
- To determine if mental distress influences the results of acetylcholine provocation tests.
Main Methods:
- 99 patients underwent intracoronary acetylcholine (ACh) provocation tests for vasospastic angina diagnosis.
- Mental health was assessed using the 12-item General Health Questionnaire (GHQ-12) and State-Trait Anxiety Inventory Form Y (STAI Y-2).
- Poor mental health was defined as GHQ-12 ≥ 4.
Main Results:
- 41% of patients exhibited poor mental health (GHQ-12 ≥ 4).
- The incidence of positive ACh provocation tests was similar between patients with and without poor mental health (49% vs. 48%).
- Factors associated with higher psychological distress scores included younger age, no prior percutaneous coronary intervention, and no diabetes mellitus.
Conclusions:
- A significant proportion of patients evaluated for vasospastic angina experience poor mental health.
- Mental distress did not demonstrate an impact on the diagnostic accuracy of the acetylcholine provocation test in this cohort.
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