Related Experiment Video

Updated: Dec 15, 2025

Intracoronary Acetylcholine Provocation Testing for Assessment of Coronary Vasomotor Disorders
06:39

Intracoronary Acetylcholine Provocation Testing for Assessment of Coronary Vasomotor Disorders

Published on: August 18, 2016

16.5K

Mental Health Status in Patients Undergoing Intracoronary Acetylcholine Provocation Test

Yuichi Saito1, Toshihiro Shoji2,3, Kazuya Tateishi2

  • 1Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan. saitoyuichi1984@gmail.com.

Advances in Therapy
|July 12, 2020
PubMed

Insights

Over 40% of patients undergoing vasospastic angina testing reported poor mental health, including anxiety and depression. However, this mental distress did not impact the acetylcholine provocation test results.

Area of Science:

  • Cardiology
  • Psychiatry
  • Clinical Medicine

Background:

  • Previous research links mental distress (anxiety, depression) to coronary vasoconstriction and myocardial ischemia.
  • The mental health status of patients with suspected vasospastic angina remains unclear.

Purpose of the Study:

  • To investigate the mental health status of patients undergoing diagnostic testing for vasospastic angina.
  • To determine if mental distress influences the results of acetylcholine provocation tests.

Main Methods:

  • 99 patients underwent intracoronary acetylcholine (ACh) provocation tests for vasospastic angina diagnosis.
  • Mental health was assessed using the 12-item General Health Questionnaire (GHQ-12) and State-Trait Anxiety Inventory Form Y (STAI Y-2).
  • Poor mental health was defined as GHQ-12 ≥ 4.

Main Results:

  • 41% of patients exhibited poor mental health (GHQ-12 ≥ 4).
  • The incidence of positive ACh provocation tests was similar between patients with and without poor mental health (49% vs. 48%).
  • Factors associated with higher psychological distress scores included younger age, no prior percutaneous coronary intervention, and no diabetes mellitus.

Conclusions:

  • A significant proportion of patients evaluated for vasospastic angina experience poor mental health.
  • Mental distress did not demonstrate an impact on the diagnostic accuracy of the acetylcholine provocation test in this cohort.
Abstract

Keywords:
Acetylcholine provocation testCardiologyMental stressVasospastic angina

More Related Videos

Acetylcholine Re-Challenge After Intracoronary Nitroglycerine Administration07:59

Acetylcholine Re-Challenge After Intracoronary Nitroglycerine Administration

Published on: April 4, 2022

1.6K
Testing Acetylcholine Followed by Adenosine for Invasive Diagnosis of Coronary Vasomotor Disorders05:58

Testing Acetylcholine Followed by Adenosine for Invasive Diagnosis of Coronary Vasomotor Disorders

Published on: February 3, 2021

4.0K

Related Concept Videos

Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
130
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
518
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
280
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
147
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
1.7K
Acute Coronary Syndrome V: Nursing Management01:26

Acute Coronary Syndrome V: Nursing Management

Nursing Assessment:Nursing management of acute coronary syndrome (ACS) involves taking the patient's history, focusing on primary complaints such as chest pain, dyspnea, and excessive sweating (diaphoresis), as well as other symptoms like back or jaw pain, nausea, vomiting, palpitations, dizziness, and fatigue. The nurse also reviews the patient's history of cardiac events, risk factors such as hypertension, diabetes, smoking, family history, and current medications.In the objective assessment,...
187