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Thalamic atrophy correlates with dysfunctional impulsivity in multiple sclerosis.

H Joly1, N Capet1, L Mondot1

  • 1Centre de Ressources et de Compétence Sclérose en Plaques CRCSEP CHU de Nice. Université Nice côté d'azur (URRIS UR2CA). hôpital Pasteur 2. 30 voie romaine, Nice 06002, France.

Multiple Sclerosis and Related Disorders
|July 12, 2020
PubMed
Summary
This summary is machine-generated.

Multiple Sclerosis (MS) patients, particularly Relapsing-Remitting MS, exhibit higher dysfunctional impulsivity (DI). This behavioral change is strongly linked to processing speed impairment and thalamic atrophy in MS.

Keywords:
BehaviourImpulsivityMRIMultiple sclerosisThalamic atrophy

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Area of Science:

  • Neuroscience
  • Clinical Neurology

Background:

  • Thalamic atrophy is increasingly recognized in Multiple Sclerosis (MS) related disorders.
  • Behavioral changes in MS are under-explored but critical for patient care.
  • Dysfunctional impulsivity (DI) is a key behavioral symptom in MS.

Purpose of the Study:

  • To determine if MS patients exhibit pathological levels of dysfunctional impulsivity (DI).
  • To assess DI frequency across different MS phenotypes, including early stages like Clinically Isolated Syndrome (CIS).
  • To identify factors contributing to abnormal impulsivity and its relationship with thalamic atrophy in MS.

Main Methods:

  • Prospective recruitment of 95 patients with demyelinating diseases (CIS, RRMS, SPMS, PPMS).
  • Comprehensive cognitive evaluations including processing speed (PSI), impulsivity (DII), depression (Fast BDI), and fatigue (EMIF-SEP).
  • MRI analysis for T2 lesion load, whole-brain, and regional atrophy, focusing on thalamus.

Main Results:

  • 7% of MS patients showed pathologically high dysfunctional impulsivity (DI).
  • Relapsing-Remitting MS (RRMS) patients had significantly higher DI than Clinically Isolated Syndrome (CIS) patients.
  • DI strongly correlated with processing speed of information (PSI) and thalamic atrophy.

Conclusions:

  • Pathological DI is present in some MS patients, notably RRMS compared to CIS.
  • Cognitive fatigue and processing speed impairment, particularly PSI slowing, significantly impact DI.
  • DI in MS is associated with both frontal lobe function and, more strongly, thalamic atrophy, suggesting a disconnection syndrome.