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Drop attacks in Menière's disease.

L M Odkvist1, J Bergenius

  • 1Department of Otolaryngology, University Hospital, Linköping, Sweden.

Acta Oto-Laryngologica. Supplementum
|January 1, 1988
PubMed
Summary
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Inner ear conditions, like Meniere disease, can cause incapacitating drop attacks. Intratympanic gentamicin effectively cured drop attacks in Meniere disease patients, confirming an inner ear origin.

Area of Science:

  • Otolaryngology
  • Neurology

Background:

  • Drop attacks are often misdiagnosed, with cardiovascular causes frequently investigated over inner ear pathologies.
  • Inner ear etiology for drop attacks is underrepresented in medical literature.
  • Meniere disease can present with severe vertigo and incapacitating drop attacks.

Purpose of the Study:

  • To investigate the efficacy of intratympanic gentamicin in treating drop attacks associated with Meniere disease.
  • To determine if drop attacks in Meniere disease patients originate from the inner ear.

Main Methods:

  • Twenty-nine patients with severe, incapacitating Meniere attacks and frequent drop attacks were treated with intratympanic gentamicin.
  • Treatment was administered after failure of all other medical interventions.

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Main Results:

  • Vertigo attacks were resolved in all but two patients.
  • All patients experienced complete resolution of drop attacks, strongly suggesting an inner ear origin.
  • Two patients experienced recurrence of inner ear symptoms.

Conclusions:

  • Intratympanic gentamicin is an effective treatment for incapacitating drop attacks in Meniere disease.
  • The complete resolution of drop attacks supports an inner ear etiology for these events in Meniere disease patients.