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Updated: Dec 15, 2025

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research
Published on: October 20, 2023
Mitro-aortic fibrosa pseudoaneurysm and concomitant aortic stenosis: How to kill two birds with a stone
Alberto Boi1, Giovanni Garau1, Angelica Rossi1
1Interventional Cardiology, Azienda Ospedaliera Brotzu, Cagliari, Sardinia, Italy.
Abstract:
Pseudoaneurysm of mitral-aortic intervalvular fibrosa (P-MAIVF) is a rare acquired malformation of the mitral-aortic intervalvular area. It appears as a pulsatile cavity in the mitral-aortic junction communicating with the left ventricular outflow tract. P-MAIVF has been reported as a complication of aortic and mitral valve surgery, infective endocarditis, and thoracic trauma. It is associated with life-threatening complications. The recommended treatment is surgery, however, conservative therapy is an alternative approach for high-risk patients or when surgical treatment is refused. We describe a successfully exclusion of a P-MAIVF by transapical transcatheter aortic valve implantation in a patient with concomitant severe aortic stenosis.
Insights
Pseudoaneurysm of the mitral-aortic intervalvular fibrosa (P-MAIVF) is a rare condition. Transapical transcatheter aortic valve implantation successfully excluded a P-MAIVF in a patient with severe aortic stenosis.
Area of Science:
- Cardiology
- Cardiac Surgery
- Interventional Cardiology
Background:
- Pseudoaneurysm of the mitral-aortic intervalvular fibrosa (P-MAIVF) is a rare acquired malformation.
- It presents as a pulsatile cavity at the mitral-aortic junction, potentially leading to life-threatening complications.
- P-MAIVF is often a complication of cardiac surgery, endocarditis, or trauma.
Observation:
- This case report details a patient with severe aortic stenosis and a concomitant P-MAIVF.
- The patient was considered high-risk for conventional surgery.
Findings:
- Successful exclusion of the P-MAIVF was achieved using a transapical transcatheter aortic valve implantation (TA-TAVI) approach.
- This minimally invasive technique provided an effective solution for a complex P-MAIVF in a high-risk patient.
Implications:
- Transcatheter aortic valve implantation may represent a viable alternative treatment for P-MAIVF, particularly in patients unsuitable for open-heart surgery.
- This approach offers a less invasive option for managing this rare but dangerous cardiac condition.
- Further research into transcatheter techniques for P-MAIVF is warranted to establish its role in clinical practice.
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