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Updated: Dec 15, 2025

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
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Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

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Regulation of Breast Cancer Progression by Noncoding RNAs

Ravishkumar L Akshaya1, Muthukumar Rohini1, Nagarajan Selvamurugan1

  • 1Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603203, Tamil Nadu, India.

Current Cancer Drug Targets
|July 13, 2020
PubMed
Abstract

Insights

Noncoding RNAs (ncRNAs), including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), are crucial in breast cancer (BC) development. Understanding their interactions offers new avenues for BC biomarkers and therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Breast cancer (BC) remains a leading cause of cancer-related mortality in women globally.
  • The molecular mechanisms driving BC invasion and metastasis are not fully understood.
  • Noncoding RNAs (ncRNAs), particularly microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), are increasingly implicated in breast carcinogenesis.

Purpose of the Study:

  • To elucidate the roles of miRNAs and lncRNAs in BC development and progression.
  • To explore the interaction mechanisms between miRNAs and lncRNAs in breast cancer.
  • To identify potential monitoring biomarkers and therapeutic strategies for BC.

Main Methods:

  • This review synthesizes current research on ncRNA involvement in BC.
  • It examines the molecular mechanisms underlying miRNA and lncRNA functions.
  • The review analyzes the interplay between different types of ncRNAs in breast cancer.

Main Results:

  • ncRNAs critically regulate key cellular processes such as cell growth, cell cycle, epithelial-mesenchymal transition (EMT), invasion, migration, and apoptosis.
  • Dysregulation of miRNAs and lncRNAs is a common feature in various cancers, including BC.
  • miRNAs and lncRNAs interact through multiple mechanisms, influencing target gene expression and acting as either tumor suppressors or oncogenes.

Conclusions:

  • miRNAs and lncRNAs are pivotal players in breast carcinogenesis.
  • Their complex interactions significantly impact BC development and progression.
  • Targeting these ncRNAs holds promise for novel BC diagnostic and therapeutic approaches.
Keywords:
Breast cancerLncRNAsMiRNAsarchetypesdysregulationmetastasis

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