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Updated: Dec 15, 2025

In Vitro Analysis of E3 Ubiquitin Ligase Function
Published on: May 14, 2021
The Regulation of E3 Ubiquitin Ligases Cbl and its Cross-talking in Bone Homeostasis
Xiaobin Yang1, Dingjun Hao1, Baorong He1
1Department of Spine Surgery, Honghui Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Abstract:
The E3 ubiquitin ligases Cbl has been found play an important role in regulating cellular proliferation and migration. Whereas, the excessive differentiation of osteoclast and/or its overexpressing of resorptive functions could lead the pathological bone homeostasis by overly bone matrix degradation. Since the first time of the important role of Cbl in the regulating osteoclast differentiation (also named osteoclastogenesis) has been reported in decades ago. The extensively studies have been conducted for in-depth exploring Cbl's definite role during osteoclastogenesis, as well as its cross talking with other signaling pathways (such as: Src and PI3K signaling) in bone homeostasis. Herein, our current study aims to briefly conclude the current studies of osteoclastogenesis and the regulatory role of Cbl, as well as its cross-talking in bone homeostasis.
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