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EQUIDopa: A responsive web application for the levodopa equivalent dose calculator.

Domen Verber1, Damijan Novak1, Mladen Borovič1

  • 1University of Maribor, Faculty of Electrical Engineering and Computer Science, Maribor, Slovenia.

Computer Methods and Programs in Biomedicine
|July 13, 2020
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Summary

A new application simplifies converting antiparkinson drugs to levodopa equivalent doses for Parkinson's disease patients on intestinal gel infusion. This tool enhances accuracy and efficiency in treatment adjustments.

Keywords:
AngularDuodopa(Ⓡ)LevodopaLevodopa equivalent dose calculatorParkinson's diseaseResponsive web application

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Area of Science:

  • Neurology
  • Medical Informatics

Background:

  • Advanced Parkinson's disease often requires levodopa/carbidopa intestinal gel infusion.
  • Converting oral antiparkinson drugs to the equivalent infusion dose is complex and prone to errors.

Purpose of the Study:

  • To develop a user-friendly application for efficient and accurate levodopa equivalent dose conversion.
  • To facilitate the treatment conversion process for patients receiving levodopa/carbidopa intestinal gel infusion.

Main Methods:

  • Calculations based on established literature and studies.
  • Evaluation of existing online conversion tools.
  • Development using modern programming tools and frameworks.

Main Results:

  • The application is effective and user-friendly in clinical practice.
  • It serves as a reliable control for manual dose calculations.
  • It is a valuable educational tool for levodopa/carbidopa intestinal gel infusion courses.

Conclusions:

  • The application efficiently replaces manual, error-prone levodopa equivalent dose conversions.
  • Offers enhanced functionality, reduced user error, and broad device compatibility compared to existing tools.
  • Provides an estimated conversion value, serving as a starting point for clinical judgment and patient-specific titration.