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Development of Antibiotic Resistance

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...

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The Use of a β-lactamase-based Conductimetric Biosensor Assay to Detect Biomolecular Interactions

The Use of a β-lactamase-based Conductimetric Biosensor Assay to Detect Biomolecular Interactions

Published on: February 1, 2018

Metallo-ß-lactamases: a review.

Payam Behzadi¹, Herney Andrés García-Perdomo², Tomasz M Karpiński³

¹Department of Microbiology, College of Basic Sciences, Shahr-e-Qods Branch, Islamic Azad University, Fath Highway, Shahr-e-Qods, End of Shahid Kalhor Blvd, Post Box: 37541-374, Tehran, Iran. behzadipayam@yahoo.com.

Molecular Biology Reports

|July 13, 2020

Summary

Metallo-ß-Lactamases (MBLs) are critical antibiotic resistance genes found in pathogens like Enterobacteriaceae. Bioinformatics aids in understanding MBLs, paving the way for developing effective inhibitors and treatments.

Keywords:

Bioinformatics Enterobacteriaceae Escherichia coli Klebsiella pneumoniae Metallo-Beta-Lactamase

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Area of Science:

Microbiology
Genetics
Bioinformatics

Background:

Antibiotic resistance genes, including Extended-Spectrum-ß-Lactamases (ESBLs) and Metallo-ß-Lactamases (MBLs), are present in Enterobacteriaceae.
MBLs pose a significant threat to global public healthcare systems.

Purpose of the Study:

This review focuses on the characteristics of MBLs.
To highlight the clinical concern and spread of MBLs among microbial pathogens.

Main Methods:

Literature search of databases (MEDLINE, SCOPUS, SCIENCEDIRECT, GOOGLE SCHOLAR) using keywords: Enterobacteriaceae, Escherichia coli, Klebsiella pneumoniae, MBL, Bioinformatics.
Selection of review and original articles published between 1980 and 2020.

Main Results:

The spread of MBLs among microbial pathogens necessitates further research for definitive treatment strategies.
Computational biology, chemistry, and bioinformatics have been instrumental in identifying MBL properties.

Conclusions:

Bioinformatic tools and databases offer promising avenues for developing effective MBL inhibitors.
Advancements in bioinformatics are crucial for combating MBL-mediated antibiotic resistance and developing targeted treatments.