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Cytotoxic steroidal glycosides from the underground parts of Hosta ventricosa
Hong-Biao Chu1, Rui Li1, Yan Gao1
1Department of Pharmacy, School of Medicine, Jinggangshan University, Ji'an 343009, China.
Abstract:
A phytochemical study on the underground parts of Hosta ventricosa yielded one new spirostanol saponin (1), two new furostanol saponins (2 and 3), and one new pregnane glycoside (4), along with three known compounds (5‒7). Their structures were elucidated on the basis of chemical and spectroscopic analysis. All isolated compounds were evaluated for their cytotoxic effects against five human cancer cell lines (HL-60, A-549, SMMC-7721, MCF-7, and SW-480). Compounds 1, 2, and 5‒7 showed cytotoxic activities with IC50 values of 3.21-17.06 μM.
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