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Updated: Dec 15, 2025

Development of an in vitro model system for studying the interaction of Equus caballus IgE with its high-affinity receptor FcεRI
Published on: November 1, 2014
Genetics of Immune Disease in the Horse
Rebecca L Tallmadge1, Douglas F Antczak2, Maria Julia Bevilaqua Felippe3
1Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, 240 Farrier Road, Ithaca, NY 14853, USA.
Abstract:
Host defenses against infection by viruses, bacteria, fungi, and parasites are critical to survival. It has been estimated that upwards of 7% of the coding genes of mammals function in immunity and inflammation. This high level of genomic investment in defense has resulted in an immune system characterized by extraordinary complexity and many levels of redundancy. Because so many genes are involved with immunity, there are many opportunities for mutations to arise that have negative effects. However, redundancy in the mammalian defense system and the adaptive nature of key immune mechanisms buffer the untoward outcomes of many such deleterious mutations.
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