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Updated: Dec 15, 2025

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Association between Interleukin-10 Gene Polymorphisms and Behcet's Disease Susceptibility: Evidence from a
Xue-Feng Li1, Zhi-Zhen Huang2, Yuan-Yuan Hu2
1Department of Endocrinology, Hubei Key Laboratory of Embryonic Stem Cell Research, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.
This meta-analysis found that interleukin-10 (IL-10) gene polymorphisms, specifically the -819T>C variant, are associated with a reduced risk of developing Behcet's disease (BD). These findings highlight IL-10's role in BD susceptibility.
Area of Science:
- Immunogenetics
- Rheumatology
- Molecular Epidemiology
Background:
- Interleukin-10 (IL-10) gene polymorphisms have been implicated in Behcet's disease (BD) susceptibility.
- Previous studies reported inconsistent findings regarding the association between IL-10 polymorphisms and BD risk.
Purpose of the Study:
- To conduct a comprehensive meta-analysis to clarify the relationship between IL-10 polymorphisms and Behcet's disease susceptibility.
- To provide a more precise assessment of IL-10's role in BD development.
Main Methods:
- Searched multiple online databases (PubMed, Embase, SCI, CNKI, WanFang) for relevant case-control studies.
- Included 15 articles comprising 36 independent studies with 5,971 BD patients and 8,913 controls.
- Analyzed IL-10 gene polymorphisms (-1082A>G, -819T>C, -592A>C) using odds ratios (OR) and 95% confidence intervals (CI).
- Assessed publication bias, performed sensitivity, and cumulative analyses to ensure robustness.
Main Results:
- Significant associations were found between the IL-10 -819T>C polymorphism and reduced BD risk across various genetic models (e.g., C vs. T: OR=0.72, P<0.01).
- The IL-10 -592 A>C polymorphism and the ACC haplotype demonstrated a significant protective effect against BD.
- The meta-analysis included a substantial sample size, enhancing statistical power.
Conclusions:
- IL-10 gene polymorphisms, particularly the -819T>C variant and -592 A>C polymorphism, are significantly associated with Behcet's disease susceptibility.
- These findings suggest that IL-10 plays a crucial role in the pathogenesis of Behcet's disease.
- Further research into IL-10's specific mechanisms in BD is warranted.
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