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Updated: Jan 22, 2026
09:41
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
12.0K
Association between interleukin-10 gene polymorphisms and multiple sclerosis susceptibility: evidence from a
Yue-Long Xu1, Yu-Ming Niu2,3
1Department of Neurology, Linyi Central Hospital, Linyi, 276400, Shandong Province, China.
Summary
Single nucleotide polymorphisms (SNPs) in the interleukin-10 (IL-10) gene are linked to multiple sclerosis (MS) risk. This meta-analysis confirms IL-10 gene variations are substantial factors in MS development.
Area of Science:
- Immunogenetics
- Neuroimmunology
- Human Genetics
Background:
- Epidemiological studies suggest a potential role for single nucleotide polymorphisms (SNPs) in the interleukin-10 (IL-10) gene in the etiology of multiple sclerosis (MS).
- Previous findings regarding the association between IL-10 gene polymorphisms and MS susceptibility have been inconsistent.
- The IL-10 gene plays a crucial role in immune regulation, making it a candidate gene for autoimmune diseases like MS.
Purpose of the Study:
- To conduct a comprehensive meta-analysis investigating the association between specific IL-10 gene polymorphisms (rs1800896, rs1800871, rs1800872) and their haplotypes with MS susceptibility.
- To consolidate and critically evaluate existing evidence to resolve inconsistencies in previous studies.
- To determine if IL-10 gene variations are significant risk factors for developing MS.
Main Methods:
- A systematic meta-analysis was performed, searching five major English-language databases (PubMed, Embase, Web of Science, CNKI, Wanfang).
- Included were 14 articles comprising 30 independent case-control studies.
- Crude odds ratios (OR) with 95% confidence intervals (CI) were calculated for IL-10 polymorphisms (-1082 A>G, -819T>C, -592 A>C), their haplotypes, and MS susceptibility. Publication bias, sensitivity, and cumulative analyses were conducted.
Main Results:
- The meta-analysis revealed significant associations between the IL-10 -1082 A>G polymorphism and MS susceptibility in the general population across various genetic models (e.g., G vs. A: OR=1.14, P=0.002; AG vs. AA: OR=1.32, P<0.001).
- Significant associations were also observed in several subgroup analyses.
- The mutant GCC haplotype of the IL-10 gene was found to significantly increase the risk of MS susceptibility.
Conclusions:
- This meta-analysis provides robust evidence suggesting that polymorphisms in the interleukin-10 (IL-10) gene are substantial genetic factors contributing to the development of multiple sclerosis (MS).
- The findings highlight the importance of specific IL-10 variants, particularly the -1082 A>G polymorphism and the GCC haplotype, in MS pathogenesis.
- Further research may explore the functional mechanisms underlying these genetic associations.
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