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Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
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Causal Relationship Between Obstructive Sleep Apnea and Temporomandibular Disorders: A Bidirectional Mendelian

Yu-Pei Wang1, Hui-Xia Wei2, Yuan-Yuan Hu3

  • 1Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, People's Republic of China.

Nature and Science of Sleep
|July 30, 2024
PubMed
Summary

Obstructive sleep apnea (OSA) causally influences temporomandibular disorders (TMD), suggesting a hereditary link. Early intervention is crucial for managing both conditions effectively.

Keywords:
Mendelian randomization analysisobstructive sleep apneatemporomandibular disorders

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Area of Science:

  • Genetics
  • Sleep Medicine
  • Oral and Maxillofacial Surgery

Background:

  • Obstructive sleep apnea (OSA) and temporomandibular disorders (TMD) are prevalent conditions.
  • The etiological relationship between OSA and TMD remains incompletely understood.

Purpose of the Study:

  • To investigate the potential bidirectional causal relationship between OSA and TMD.
  • To explore the genetic underpinnings of the association between OSA and TMD.

Main Methods:

  • Utilized a two-sample bi-directional Mendelian randomization (MR) approach.
  • Employed inverse variance weighting as the primary analysis method, supplemented by MR-Egger, weighted median, simple mode, and weighted mode analyses.
  • Assessed heterogeneity and validity using Cochran Q, MR-Egger, and MR-PRESSO tests.

Main Results:

  • Forward MR analysis revealed a significant causal effect of OSA on TMD (OR=1.241, P=0.041).
  • Reverse MR analysis showed no significant causal influence of TMD on OSA (IVW: OR=0.975, P=0.411).

Conclusions:

  • Established a hereditary causative relationship where OSA influences TMD.
  • Highlights the need for integrated prevention and treatment strategies for both OSA and TMD.