Translational Toxicology in Zebrafish

Area of Science:

• Translational toxicology
• Chemical safety assessment
• Comparative toxicology

Background:

• Translational toxicology aims to identify and understand adverse chemical effects across systems.
• Key activities include toxicity assessment, mode-of-action determination, computational prediction, and intervention identification.
• The zebrafish offers a unique combination of mammalian and invertebrate model advantages.

Purpose of the Study:

• To review the utility of zebrafish in translational toxicology.
• To demonstrate zebrafish applicability across all four core activities of translational toxicology.
• To identify data gaps and challenges in zebrafish-based translational toxicology.

Main Methods:

• Literature review of recent studies using zebrafish in toxicology.
• Analysis of research addressing chemical toxicity, mode-of-action, prediction, and interventions.
• Evaluation of zebrafish model strengths and limitations.

Main Results:

• Zebrafish effectively model chemical toxicity across life stages.
• The model aids in elucidating toxic modes of action.
• Zebrafish facilitate computational toxicology predictions and intervention discovery.
• Literature supports zebrafish utility in all four translational toxicology activities.

Conclusions:

• Zebrafish are a versatile and powerful model organism for translational toxicology.
• Further research is needed to address existing data gaps and challenges.
• Optimizing zebrafish use will advance chemical safety and health protection strategies.