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Hypothalamic changes during the immune response.

H Besedovsky, E Sorkin, D Felix

    European Journal of Immunology
    |May 1, 1977
    PubMed
    Summary
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    The immune system communicates with the brain. Activated immune cells signal the hypothalamus, indicating the brain

    Area of Science:

    • Neuroimmunology
    • Neuroendocrinology
    • Physiology

    Background:

    • Immunoregulation involves autoregulatory processes.
    • A potential role for immune-neuroendocrine interactions in immunoregulation is explored.

    Purpose of the Study:

    • To investigate the communication between the immune system and the hypothalamus.
    • To determine if immune activation influences neuronal activity in the rat hypothalamus.

    Main Methods:

    • Electrophysiological recordings were used to measure neuronal activity in specific hypothalamic nuclei (ventromedial and anterior).
    • The effects of two antigens on neuronal firing rates were assessed in rats.

    Main Results:

    • Two antigens significantly increased electrical activity (>100%) in individual neurones of the ventromedial hypothalamus.

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  • No significant increase in neuronal firing rate was observed in the anterior nucleus of the hypothalamus.
  • Rats that did not respond to antigen showed no increase in hypothalamic neuronal firing rate.

    • Conclusions:

    • These findings provide the first evidence of information flow from the activated immune system to the hypothalamus.
    • Suggests the brain, specifically the hypothalamus, plays a role in the immune response.
    • Highlights the potential of immune-neuroendocrine interactions in regulating immune processes.