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Pros and cons of corticosteroid therapy for COVID-19 patients

Paula Mattos-Silva1, Nathane Santanna Felix1, Pedro Leme Silva1

  • 1Laboratory of Pulmonary Investigation, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Respiratory Physiology & Neurobiology
|July 14, 2020
PubMed

Insights

Corticosteroids may help manage COVID-19 (coronavirus disease 2019) as a supportive treatment. This communication reviews the benefits and drawbacks of using corticosteroids for COVID-19 patients based on current evidence.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Critical Care Medicine

Background:

  • The global emergence of coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, necessitates urgent therapeutic strategies.
  • Severe pneumonia associated with COVID-19 requires effective management options.

Purpose of the Study:

  • To evaluate the role of corticosteroids as an adjunctive therapy in managing COVID-19.
  • To outline the advantages and disadvantages of corticosteroid use in COVID-19 treatment.

Main Methods:

  • Review of current scientific literature and clinical evidence.
  • Analysis of the pharmacological effects of corticosteroids in viral infections.

Main Results:

  • Corticosteroids demonstrate potential benefits in reducing inflammation and improving outcomes in certain COVID-19 patients.
  • Potential risks and contraindications associated with corticosteroid use require careful consideration.

Conclusions:

  • Corticosteroids can be a valuable adjunctive therapy for managing severe COVID-19.
  • Evidence supports a balanced approach, weighing benefits against risks for individual patient management.

Keywords:
COVID-19DexamethasoneInflammationSARS-COV-2Steroids

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