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Related Experiment Video

Updated: Dec 15, 2025

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
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A validation study for remote testing of cognitive function in multiple sclerosis.

Lisa F Barcellos1, Mary Horton2, Xiaorong Shao2

  • 1Division of Epidemiology & Biostatistics, Genetic Epidemiology and Genomics Laboratory, School of Public Health, University of California Berkeley, Berkeley, CA, USA/Kaiser Permanente Division of Research, Oakland, CA, USA.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|July 15, 2020
PubMed
Summary
This summary is machine-generated.

Remote cognitive assessments using the Symbol Digit Modalities Test (SDMT) and California Verbal Learning Test (CVLT-II) are valid and reliable for multiple sclerosis (MS) patients. This approach offers a dependable method for monitoring cognitive function remotely.

Keywords:
CVLT-IIMultiple sclerosisSDMTcognitive impairment

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Area of Science:

  • Neuroscience
  • Clinical Psychology
  • Rehabilitation Medicine

Background:

  • Cognitive impairment is a significant challenge in multiple sclerosis (MS) management.
  • Traditional in-person cognitive assessments can be burdensome for MS patients.
  • Developing remote assessment tools is crucial for accessible and frequent monitoring.

Purpose of the Study:

  • To determine the validity and reliability of a remote, technician-guided cognitive assessment for MS.
  • To incorporate the Symbol Digit Modalities Test (SDMT) and California Verbal Learning Test, Second Edition (CVLT-II) into a remote testing protocol.

Main Methods:

  • Compared in-person cognitive testing with remote, web-assisted assessments in 100 MS patients.
  • Assessed test-retest reliability in 36 MS patients using equivalent, alternative forms of the SDMT and CVLT-II.

Main Results:

  • Remote and in-person SDMT (r=0.85) and CVLT-II (r=0.71) scores showed strong agreement.
  • Test-retest reliability for remote SDMT (r=0.92) and CVLT-II (r=0.81) was adequate, with alternative forms yielding similar results.

Conclusions:

  • Remote cognitive assessment provides valid and reliable measures of cognitive function in MS.
  • Technician-guided remote testing is a viable alternative to in-person assessments for MS.
  • This methodology supports remote monitoring of cognitive health in MS patients.