The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research.

Area of Science:

• Life Sciences
• Biomedical Research
• Laboratory Animal Science

Background:

• Reproducible science hinges on transparent reporting of in vivo experiments.
• The original ARRIVE guidelines (2010) aimed to enhance reporting quality but faced inconsistent adherence.
• Lack of consistent application hindered improvements in animal research reporting.

Purpose of the Study:

• Introduce ARRIVE 2.0, an updated version of the ARRIVE guidelines.
• Facilitate practical implementation through reorganized information and a stepwise approach.
• Improve the rigour and transparency of animal research reporting to enhance reproducibility.

Main Methods:

• Updated the ARRIVE guidelines with reorganized information.
• Utilized a Delphi exercise to prioritize and categorize guideline items.
• Developed an Explanation and Elaboration (E&E) document for clarity and rationale.

Main Results:

• Divided guideline items into the "ARRIVE Essential 10" (minimum requirements) and the "Recommended Set" (research context).
• The updated structure supports a stepwise implementation approach for better adherence.
• The E&E document provides rationale, clarifies concepts, and offers examples for each guideline item.

Conclusions:

• ARRIVE 2.0 aims to equip researchers, reviewers, and editors to improve scientific rigour and transparency.
• The updated guidelines and supporting documents are designed to enhance the reproducibility of animal research.
• Implementation of ARRIVE 2.0 is expected to lead to more robust and transparent in vivo experimental reporting.