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Updated: Dec 15, 2025

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets
Published on: May 11, 2015
[Current Aspects of Definition and Diagnosis of Pulmonary Hypertension]
T J Lange1, M Borst2, R Ewert3
1Uniklinik Regensburg, Klinik für Innere Medizin II, Bereich Pneumologie, Regensburg.
Insights
The 6th World Symposium on Pulmonary Hypertension lowered the diagnostic threshold for pulmonary hypertension (PH) to >20 mmHg and included pulmonary vascular resistance. This impacts PH diagnosis and management.
Area of Science:
- Cardiology
- Pulmonology
- Medical Diagnostics
Background:
- The 6th World Symposium on Pulmonary Hypertension (WSPH) convened in 2018 to review advancements in PH over the preceding five years.
- Key findings were published, introducing significant revisions to the diagnostic criteria for PH.
Purpose of the Study:
- To discuss the rationale and implications of the revised PH definition proposed by the WSPH.
- To provide an updated overview of diagnostic and prognostic methods for PH.
Main Methods:
- Review of scientific progress presented at the 6th WSPH.
- Analysis of the proposed changes to the PH definition, including diagnostic thresholds and criteria.
- Overview of current non-invasive and invasive diagnostic techniques, including exercise testing.
Main Results:
- The WSPH recommended lowering the diagnostic threshold for PH from ≥25 mmHg to >20 mmHg mean pulmonary arterial pressure.
- Pulmonary vascular resistance was incorporated into the definition of PH, emphasizing cardiac output measurement.
- The article discusses the potential consequences of these definition changes.
Conclusions:
- The revised definition of PH signifies a major shift in diagnostic criteria.
- Understanding these changes is crucial for accurate diagnosis, differential diagnosis, and prognosis of PH.
- A comprehensive approach integrating updated definitions and diagnostic methods is essential for managing pulmonary hypertension.
Abstract:
At the 6th World Symposium on Pulmonary Hypertension (WSPH), which took place from February 27 until March 1, 2018 in Nice, scientific progress over the past 5 years in the field of pulmonary hypertension (PH) was presented by 13 working groups. The results of the discussion were published as proceedings towards the end of 2018. One of the major changes suggested by the WSPH was the lowering of the diagnostic threshold for PH from ≥ 25 to > 20 mmHg mean pulmonary arterial pressure, measured by right heart catheterization at rest. In addition, the pulmonary vascular resistance was introduced into the definition of PH, which underlines the importance of cardiac output determination at the diagnostic right heart catheterization.In this article, we discuss the rationale and possible consequences of a changed PH definition in the context of the current literature. Further, we provide a current overview on non-invasive and invasive methods for diagnosis, differential diagnosis, and prognosis of PH, including exercise tests.
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