Related Experiment Video
Updated: Dec 14, 2025

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
Simultaneous Analysis of Paracetamol and Diclofenac Using MWCNTs-COOH Modified Screen-Printed Carbon Electrode and
Agnieszka Sasal1, Katarzyna Tyszczuk-Rotko1, Magdalena Wójciak2
1Faculty of Chemistry, Institute of Chemical Sciences, Maria Curie-Skłodowska University in Lublin, 20-031 Lublin, Poland.
Abstract:
A differential-pulse adsorptive stripping voltammetric (DPAdSV) procedure with the use of pulsed potential accumulation and carboxyl functionalized multiwalled carbon nanotubes modified screen-printed carbon electrode (SPCE/MWCNTs-COOH) was delineated for simultaneous analysis of paracetamol (PA) and diclofenac (DF). The use of carboxyl functionalized MWCNTs and pulsed potential accumulation improves the analytical signals of PA and DF, and minimizes interferences from surfactants. After optimization of analytical conditions for this sensor, the peak currents of the two compounds were found to increase linearly with the increase in their concentration (5.0 × 10-9-5.0 × 10-6 mol L-1 with a detection limit of 1.4 × 10-9 mol L-1 for PA, and 1.0 × 10-10-2.0 × 10-8 mol L-1 with a detection limit of 3.0 × 10-11 mol L-1 for DF). For the first time, the electrochemical sensor allows simultaneous determination of PA and DF at concentrations of 24.3 ± 0.5 nmol L-1 and 3.7 ± 0.7 nmol L-1, respectively, in wastewater samples purified in a sewage treatment plant.
Related Concept Videos
Voltammetric Techniques: Linear-Scan (E vs Time)
Voltammetric Techniques: Pulse Voltammetry
Controlled-Potential Coulometry: Electrolytic Methods
The chosen potential...
Capillary Electrophoresis: Applications
Capillary zone electrophoresis (CZE) separates ionic components based on their electrophoretic mobility. It has been used to separate proteins, amino acids,...

