Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Capillary ratchets activated by interfacial flows for versatile torque generation and microassembly.

Science advances·2026

Same author

IrTMes - a stable SABRE catalyst for the hyperpolarization of [1-<sup>13</sup>C]-pyruvate.

The Analyst·2026

Same author

Development of a novel glucose online analysis approach in fermentation: Combining PLS and SVR for Raman spectroscopy with extensive validation.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2026

Same author

Miniaturization and Optimization of NMR Shimsets Allow Efficient Field Shimming.

Analytical chemistry·2026

Same author

Minimalist optical system for achromatic imaging within extended field of view based on monolithic integrated meta-axicon cluster.

Light, science & applications·2026

Same author

Finite elements and moving asymptotes accelerate quantum optimal control-FEMMA.

The Journal of chemical physics·2026

Same journal

Correction: Kang et al. Fluid Flow to Electricity: Capturing Flow-Induced Vibrations with Micro-Electromechanical-System-Based Piezoelectric Energy Harvester. <i>Micromachines</i> 2024, <i>15</i>, 581.

Micromachines·2026

Same journal

Femtosecond Laser Texturing of Wood Coatings with Bio-Based Epoxy and Wax Additives for Enhanced Hydrophobicity.

Micromachines·2026

Same journal

Engineering of Optoelectronic Devices for Renewable Energy Applications.

Micromachines·2026

Same journal

Phase Transformation and Electrochemical Behavior of Hexagonal TiO<sub>2</sub> Nanotubes Under Different Annealing Temperatures and Heating Rates.

Micromachines·2026

Same journal

Process Optimization and Predictive Modeling of Femtosecond Laser Precision Milling for Commercial PMMA Slices.

Micromachines·2026

Same journal

A Hybrid Preprocessing Multi-Objective Surrogate Model for Thermal MEMS Actuators.

Micromachines·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Dec 14, 2025

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Published on: September 19, 2017

Optofluidic Formaldehyde Sensing: Towards On-Chip Integration.

Daniel Mariuta^1,2, Arumugam Govindaraji¹, Stéphane Colin²

¹Institute of Microstructure Technology, Campus Nord, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany.

|July 16, 2020

Summary

This summary is machine-generated.

This study developed a microfluidic sensor for detecting airborne formaldehyde (HCHO) using fluorescence. A silicon-based fluidic cell demonstrated superior performance for real-time HCHO monitoring.

Keywords:

3,5–diacetyl-1,4-dihydrolutidine (DDL)SU-8 2015 waveguide light emitting diode (LED)-induced fluorescence metal-oxide-semiconductor (CMOS)-based fluorescence sensing silicon fluidic cell

More Related Videos

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

Fluorescence detection methods for microfluidic droplet platforms

Fluorescence detection methods for microfluidic droplet platforms

Published on: December 10, 2011

Related Experiment Videos

Last Updated: Dec 14, 2025

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Published on: September 19, 2017

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

Fluorescence detection methods for microfluidic droplet platforms

Fluorescence detection methods for microfluidic droplet platforms

Published on: December 10, 2011

Area of Science:

Analytical Chemistry
Microfluidics
Optical Sensing

Background:

Formaldehyde (HCHO) is a volatile indoor air pollutant from household products.
Miniaturized analytical systems offer potential for sensitive, real-time monitoring.
On-chip integration of HCHO sensing is a key challenge.

Purpose of the Study:

To prototype an on-chip formaldehyde sensing system using the Hantzsch reaction and fluorescence.
To develop efficient airborne HCHO trapping in a microfluidic device.
To create a sensitive molecular sensing system for low interrogation volumes.

Main Methods:

Developed a microfluidic system for HCHO trapping and derivatization.
Utilized the Hantzsch reaction to form 3,5-diacetyl-1,4-dihydrolutidine (DDL).
Employed an ultra-low light CMOS image sensor for fluorescence detection.

Main Results:

Tested two fluidic cell configurations: quartz-SU-8-quartz and silicon-SU-8-quartz (3.5 µL volume).
Successfully detected 10 µg/L formaldehyde concentration in both cell types.
Achieved a higher signal-to-noise ratio (SNR) with the silicon fluidic cell (SNR=6.1) compared to quartz (SNR=4.9).

Conclusions:

The CMOS-based fluorescence system is capable of detecting airborne formaldehyde.
Silicon fluidic cells offer enhanced signal intensity due to higher absorption coefficients.
This work represents initial steps towards integrated, portable HCHO monitoring devices.