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Mitochondrial pyruvate carrier: a potential target for diabetic nephropathy

Huanhuan Zhu1, Huiting Wan1, Lin Wu1

  • 1Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, 300 Guangzhou Road, Nanjing, 210029, Jiangsu Province, P. R. of China.

BMC Nephrology
|July 16, 2020
PubMed
Summary

Mitochondrial pyruvate carrier (MPC) proteins, MPC1 and MPC2, are reduced in diabetic nephropathy (DN) patients. Lower MPC levels correlate with impaired kidney function in DN.

Keywords:
Diabetic nephropathyMitochondriaMitochondrial pyruvate carrier

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