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Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD
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Preliminary Investigation of Association between Methylphenidate and Serum Growth Markers in Children with

Woo Jin Kim1, Young Rong Bang2, Je-Wook Kang3

  • 1Department of Psychiatry, Dong-A University Graduate School of Medicine, Busan, Korea.

Soa--Ch'Ongsonyon Chongsin Uihak = Journal of Child & Adolescent Psychiatry
|July 16, 2020
PubMed

Insights

Methylphenidate (MPH) did not show significant associations with growth markers in children with attention-deficit/hyperactivity disorder (ADHD). Further longitudinal studies are needed to confirm these findings on growth trajectory.

Area of Science:

  • Pediatric endocrinology
  • Neurodevelopmental disorders
  • Pharmacology

Background:

  • Methylphenidate (MPH) is a common treatment for attention-deficit/hyperactivity disorder (ADHD).
  • Concerns exist regarding MPH's potential impact on growth in pediatric populations.
  • Serum biological markers are crucial for assessing growth and development.

Purpose of the Study:

  • To investigate the association between MPH treatment and serum biological markers of growth in children diagnosed with ADHD.
  • To compare growth markers between MPH-treated children, drug-naive children with ADHD, and control subjects.

Main Methods:

  • Cross-sectional study involving 103 children with ADHD (64 drug-naive, 39 MPH-treated) and 112 controls.
  • Diagnosis of ADHD confirmed via semi-structured interview.
  • Measurement of serum markers: IGF-I, TSH, free T4, calcium, phosphorus, ALP, vitamin D, hemoglobin, total protein, albumin, total cholesterol, hematocrit.

Main Results:

  • No significant intergroup differences were observed in most growth markers.
  • Thyroid-stimulating hormone (TSH) levels were lower in MPH-treated boys with ADHD compared to drug-naive and control groups (p < 0.05).
  • All measured TSH levels remained within the normal physiological range across all groups.

Conclusions:

  • This cross-sectional study found no significant association between methylphenidate (MPH) and serum growth markers in children with ADHD.
  • Prospective longitudinal research is recommended to definitively assess MPH's effect on the growth trajectory in children.
  • Further investigation is warranted to understand the clinical significance of observed TSH level differences.
Abstract

Keywords:
ADHDCase-control studyGrowthMethylphenidateSide effect

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