Related Experiment Video
Updated: Dec 14, 2025

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Published on: September 20, 2019
Non-adjustment for multiple testing in multi-arm trials of distinct treatments: Rationale and justification
Richard A Parker1, Christopher J Weir1
1Edinburgh Clinical Trials Unit, Usher Institute, The University of Edinburgh, Edinburgh, UK.
Abstract:
There is currently a lack of consensus and uncertainty about whether one should adjust for multiple testing in multi-arm trials of distinct treatments. A detailed rationale is presented to justify non-adjustment in this situation. We argue that non-adjustment should be the default starting position in simple multi-arm trials of distinct treatments.
Related Concept Videos
Multiple Comparison Tests
It would be easy to compare two samples using a significance alpha level of 0.05. In other words, there is only one sample pair to be compared. However, it would be difficult to identify a significantly different sample if the number...
Bonferroni Test
The means of different samples are first paired in all possible combinations.
The null hypothesis of the...
Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs
Blinding
Friedman Two-way Analysis of Variance by Ranks
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...

