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Related Experiment Video

Updated: Dec 14, 2025

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Mode-multiplex plasmonic sensor for multi-analyte detection.

Firoz Haider, Rifat Ahmmed Aoni, Rajib Ahmed

    Optics Letters
    |July 16, 2020
    PubMed
    Summary

    This study introduces a novel grapefruit photonic crystal fiber sensor for simultaneous detection of three analytes using surface plasmon resonance. It achieves high sensitivity, paving the way for advanced biomolecular interaction analysis.

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    Area of Science:

    • Photonics
    • Nanotechnology
    • Biomedical Sensing

    Background:

    • Miniaturized sensors are crucial for simultaneous, real-time detection of multiple biomolecules.
    • Surface Plasmon Resonance (SPR) offers high sensitivity for detecting refractive index changes.
    • Photonic Crystal Fibers (PCFs) provide unique light-confining properties for sensor development.

    Purpose of the Study:

    • To demonstrate a novel mode-multiplex grapefruit PCF-based SPR sensor.
    • To enable simultaneous detection and quantification of three different analytes.
    • To investigate the sensor's performance and potential applications in biomolecular interaction analysis.

    Main Methods:

    • Utilized a grapefruit-shaped PCF with gold-coated air-holes as mode-multiplex channels.
    • Employed the finite element method (FEM) for sensor performance investigation and optimization.
    • Fabricated the optimized fiber structure using the standard stack-and-draw method.

    Main Results:

    • Achieved high wavelength sensitivities: 2000 nm/RIU (channel 1), 18,000 nm/RIU (channel 3) for y-polarized mode, and 3000 nm/RIU (channel 2) for x-polarized mode.
    • Demonstrated simultaneous detection of three unknown analytes.
    • Reported the highest sensitivity to date for a mode-multiplex grapefruit PCF-SPR sensor.

    Conclusions:

    • The developed grapefruit PCF-SPR sensor successfully enables simultaneous detection of multiple analytes.
    • The sensor exhibits high sensitivity, making it suitable for real-time biomolecular interaction studies.
    • This technology holds promise for applications in binding affinity analysis and diagnostics.