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Versatile Polypeptide-Functionalized Plasmonic Paper as Synergistic Biocompatible and Antimicrobial Nanoplatform
Leopold Tie1,2, Mina Răileanu3,4, Mihaela Bacalum3
1Nanobiophotonics and Laser Microspectroscopy Center, Interdisciplinary Research Institute on Bio-Nano-Sciences, Babes-Bolyai University, Treboniu Laurean No.42, 400271 Cluj-Napoca, Romania.
Molecules (Basel, Switzerland)
|July 17, 2020
Summary
This study introduces a novel gold nanoparticle-infused paper platform functionalized with a synthetic polypeptide. This biocompatible material demonstrates potent antimicrobial activity against bacteria, offering a potential antibiotic-free treatment against infections.
Area of Science:
- Nanotechnology
- Materials Science
- Biomedical Engineering
Background:
- Nanotechnology advancements enable innovative nanomaterials for combating pathogenic illnesses.
- Plasmonic nanoplatforms offer unique properties for biomedical applications.
Purpose of the Study:
- To develop a versatile, biocompatible plasmonic nanoplatform on Whatman paper.
- To functionalize the platform with a synthetic polypeptide (P2) for antimicrobial activity.
Main Methods:
- Gold nanospheres were incorporated onto Whatman paper via immersion.
- Surface functionalization with polypeptide P2 was confirmed using fluorescence spectroscopy.
- Morphological characterization was performed using scanning electron microscopy (SEM) and high-resolution transmission electron microscopy (HRTEM).
Main Results:
- The engineered plasmonic paper exhibited non-cytotoxicity towards human fibroblast cells.
- The P2-functionalized plasmonic paper achieved up to 100% inhibition of planktonic *Staphylococcus aureus* and *Escherichia coli*.
- Effective inhibition of bacterial biofilms was also observed.
Conclusions:
- The developed nanoplatform is biocompatible and possesses significant antimicrobial properties.
- This approach offers a promising strategy for antibiotic-free treatments against pathogenic bacteria.
- The functionalized plasmonic paper represents a novel material for infection control applications.
