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Updated: Dec 14, 2025
The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
Published on: April 10, 2015
Water-soluble amphiphilic ruthenium(ii) polypyridyl complexes as potential light-activated therapeutic agents
Sandra Estalayo-Adrián1, Salvador Blasco, Sandra A Bright
1School of Chemistry and Trinity Biomedical Sciences Institute (TBSI), Trinity College Dublin, The University of Dublin, Dublin 2, Ireland. estalays@tcd.ie gunnlaut@tcd.ie.
Abstract:
Two water-soluble amphiphilic Ru(ii) polypyridyl complexes containing N-1,10-phenanthrolin-5-yldocosanamide and 1,10-phenanthroline (phen) or 1,4,5,8-tetraazaphenanthrene (TAP) as ligands were synthesised and their photophysical and photobiological properties evaluated; both complexes showed a rapid cellular uptake and displayed phototoxicity against HeLa cervical cancer cells.
