Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

5.0K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.0K
Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

3.6K
A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
3.6K
Accessory Structures of the Skin: Hair Growth and Types01:20

Accessory Structures of the Skin: Hair Growth and Types

2.1K
Hair growth begins with the production of keratinocytes by the basal cells of the hair bulb. As new cells are deposited at the hair bulb, the hair shaft is pushed through the follicle toward the surface. Keratinization is completed as the cells are pushed to the skin surface to form the shaft of hair that is externally visible. The external hair is completely dead and composed entirely of keratin. Hair can be cut or shaven without damaging the hair structure because the cut is superficial. Most...
2.1K
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

4.0K
A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
4.0K
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

579
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
579
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.0K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Potential role of tirzepatide, a dual GLP-1 and GIP receptor agonist, for preventive treatment of migraine: A case series.

Headache·2026
Same author

The 2025 Scottsdale Headache Symposium: New beginnings.

Headache·2025
Same author

The 2024 Scottsdale Headache Symposium: A banner year.

Headache·2024
Same author

Evaluation of vascular risk in patients with migraine with and without aura treated with erenumab: Post hoc analysis of pooled long-term clinical trial data.

Headache·2023
Same author

Raynaud's phenomenon associated with calcitonin gene-related peptide receptor antagonists case report.

Headache·2022
Same author

Dermatologic Symptoms and Syndromes Associated with Headache.

Current pain and headache reports·2022

Related Experiment Video

Updated: Dec 14, 2025

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis
06:41

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis

Published on: March 9, 2015

9.3K

Cephalgia Alopecia.

Kate O Bedrin1, Carrie Dougherty2

  • 1Department of Neurology, MedStar Georgetown University Hospital, 3800 Reservoir Road NW, 7-PHC, Washington, DC, 20007, USA.

Current Pain and Headache Reports
|July 17, 2020
PubMed
Summary
This summary is machine-generated.

Cephalgia alopecia, a rare headache disorder causing scalp pain and hair loss, is treated with OnabotulinumtoxinA (onabotA). Research suggests a link between head pain and skin changes, with onabotA showing promise for both symptoms.

Keywords:
Alopecia areataCephalgia alopeciaHeadacheNummular headache

More Related Videos

Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia
03:22

Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia

Published on: January 27, 2018

15.5K
Author Spotlight: Minimally Invasive Relief for Occipital Neuralgia at the Nuchal Line
04:06

Author Spotlight: Minimally Invasive Relief for Occipital Neuralgia at the Nuchal Line

Published on: September 13, 2024

2.9K

Related Experiment Videos

Last Updated: Dec 14, 2025

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis
06:41

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis

Published on: March 9, 2015

9.3K
Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia
03:22

Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia

Published on: January 27, 2018

15.5K
Author Spotlight: Minimally Invasive Relief for Occipital Neuralgia at the Nuchal Line
04:06

Author Spotlight: Minimally Invasive Relief for Occipital Neuralgia at the Nuchal Line

Published on: September 13, 2024

2.9K

Area of Science:

  • Neurology
  • Dermatology
  • Headache Medicine

Background:

  • Cephalgia alopecia is a rare disorder characterized by head and neck pain followed by localized hair loss.
  • The condition is linked to neuroregulation involving the trigeminal and upper cervical nerves.

Purpose of the Study:

  • To review the clinical presentation, pathophysiology, diagnosis, and treatment of cephalgia alopecia.
  • To examine reported cases, including the initial report from 2006.

Main Methods:

  • Review of reported cases of cephalgia alopecia.
  • Analysis of clinical descriptions, pathophysiology, and treatment responses.

Main Results:

  • Pathophysiology involves recurrent activation of cranial nerves leading to substance P and CGRP depletion, affecting hair growth and immune regulation.
  • OnabotulinumtoxinA (onabotA) is the primary treatment for both headache and hair loss.
  • A case report suggests cephalgia alopecia may be part of a disease spectrum with nummular headache and trophic changes.

Conclusions:

  • Cephalgia alopecia is a rare headache disorder with associated hair loss, effectively managed with onabotA.
  • Further research is needed to explore the hypothesized disease continuum and optimize onabotA treatment techniques.