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Perioperative Propranolol: A Useful Adjunct for Glaucoma Surgery in Sturge-Weber Syndrome

Sushmita Kaushik1, Pankaj Kataria1, Gunjan Joshi1

  • 1Advanced Eye Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Ophthalmology. Glaucoma
|July 17, 2020
PubMed

Insights

Perioperative oral propranolol significantly reduced sight-threatening choroidal effusions in Sturge-Weber syndrome (SWS) patients undergoing glaucoma surgery. This treatment appears safe and effective for managing ocular complications in SWS.

Area of Science:

  • Ophthalmology
  • Vascular Disorders
  • Pharmacology

Background:

  • Sturge-Weber syndrome (SWS) presents ocular issues like choroidal hemangioma and glaucoma.
  • Glaucoma surgery in SWS patients risks sight-threatening choroidal effusions.
  • The efficacy of propranolol for choroidal hemangioma is understudied.

Purpose of the Study:

  • To investigate the role of perioperative oral propranolol in preventing choroidal effusions during glaucoma surgery in SWS patients.
  • To assess the safety and efficacy of propranolol in this context.

Main Methods:

  • A prospective, nonrandomized case series of 14 eyes from 12 SWS patients undergoing glaucoma surgery.
  • Patients received oral propranolol (2 mg/kg/day) preoperatively and postoperatively.
  • Outcomes were compared to historical controls (15 eyes from 14 patients) who did not receive propranolol.

Main Results:

  • No patients in the propranolol group developed sight-threatening choroidal effusions.
  • Two patients with bilateral SWS had peripheral effusions that resolved with medical management.
  • The control group experienced a higher incidence of choroidal effusions, some requiring surgical intervention.
  • No adverse effects of propranolol were observed.

Conclusions:

  • Perioperative oral propranolol appears effective in minimizing sight-threatening choroidal effusions after glaucoma surgery in SWS patients.
  • Propranolol demonstrates a favorable safety profile in this patient population.
  • This approach may improve surgical outcomes for SWS patients with glaucoma.
Abstract

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