[Peripheral T cell lymphomas: diagnosis and treatment]

Area of Science:

• Hematology
• Oncology
• Pathology

Background:

• Peripheral T cell lymphomas (PTCLs) are rare, aggressive hematologic malignancies.
• The 2016 WHO classification outlines several PTCL subtypes with heterogeneous global distribution, notably differing between Western and Asian populations.
• Clinical presentations frequently involve extranodal sites, B symptoms, and immune dysregulation, complicating accurate diagnosis.

Purpose of the Study:

• To highlight the diagnostic challenges in Peripheral T cell lymphomas.
• To review the current treatment landscape and prognosis associated with PTCLs.
• To underscore the need for further research into novel therapeutic strategies for PTCLs.

Main Methods:

• Review of the 2016 WHO classification for Peripheral T cell lymphomas.
• Analysis of epidemiological data regarding global distribution.
• Examination of clinical presentation and diagnostic considerations.
• Evaluation of treatment outcomes and prognostic factors.

Main Results:

• Peripheral T cell lymphomas exhibit heterogeneous worldwide distribution.
• Accurate diagnosis requires experienced pathologists collaborating with clinical data.
• Standard anthracycline-based regimens are associated with poor prognosis in PTCLs.

Conclusions:

• Peripheral T cell lymphomas present diagnostic complexities due to varied clinical features and subtypes.
• Improved diagnostic accuracy relies on integrated clinicopathological assessment.
• Further investigation into intensified treatment regimens and targeted agents is crucial for improving outcomes in PTCL patients.