Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

1.3K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
1.3K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.4K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.4K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

1.0K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
1.0K
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

10.0K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
10.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Kaposi sarcoma and Kaposi inflammatory cytokine syndrome following allogeneic haematopoietic stem cell transplantation: A case report.

British journal of haematology·2025
Same author

[Neuropathy in a 56 year-old woman].

La Revue de medecine interne·2024
Same author

Intravenous immunoglobulin as a rescue therapy for severe adult autoimmune hemolytic anemia: Results from a French multicenter observational study.

American journal of hematology·2024
Same author

[Management of hypogammaglobulinemia].

La Revue de medecine interne·2023
Same author

La Revue de medecine interne·2023
Same author

La Revue de medecine interne·2023

Related Experiment Video

Updated: Oct 10, 2025

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
08:52

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

17.4K

[HHV-8 Related immunological and hematological diseases].

F Blaison1, J Galtier2, M Parrens3

  • 1Service de médecine interne et maladies infectieuses, centre de compétence de la maladie de Castleman, hôpital Haut Lévêque CHU de Bordeaux, 33600 Pessac, France.

La Revue De Medecine Interne
|December 13, 2021
PubMed
Summary

Human herpesvirus 8 (HHV-8) causes Kaposi

Keywords:
Castleman diseaseHerpèsvirus humain type-8Human herpes-virus type 8Kaposi's sarcoma-associated herpesvirusLymphoma of the immunocopromisedMaladie de CastlemanPrimary effusion lymphomaVirus associé au sarcome de Kaposilymphomes associés aux séreuseslymphomes de l’immunodéprimé

More Related Videos

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
08:04

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

16.0K
Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
08:44

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

2.6K

Related Experiment Videos

Last Updated: Oct 10, 2025

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
08:52

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

17.4K
Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
08:04

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

16.0K
Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
08:44

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

2.6K

Area of Science:

  • Oncology
  • Virology
  • Immunology

Background:

  • Human herpesvirus 8 (HHV-8), a gammaherpesvirus, is linked to Kaposi's sarcoma and aggressive B-cell lymphoproliferative disorders, often in immunocompromised individuals.
  • HHV-8 can induce cytokine storms, leading to Castleman's disease and KSHV Inflammatory Cytokine Syndrome (KICS), and also drives lymphomagenesis.
  • Associated lymphomas include primary effusion lymphoma and diffuse large B-cell lymphoma, while germinotropic lymphoproliferative disorders present with indolent adenopathy.

Purpose of the Study:

  • To review the current understanding of HHV-8 related hematologic and immunologic complications.
  • To update on the clinical presentation, diagnostic approaches, and management strategies for HHV-8 associated conditions.

Main Methods:

  • Comprehensive literature review of HHV-8 associated diseases.
  • Analysis of diagnostic criteria and histological findings for differentiation.
  • Synthesis of current management guidelines for related hematologic disorders.

Main Results:

  • HHV-8 presents diverse clinical manifestations, ranging from reactive syndromes to aggressive lymphomas.
  • Accurate histological diagnosis is crucial for distinguishing between different HHV-8 driven entities.
  • Management strategies vary based on the specific HHV-8 associated hematologic complication.

Conclusions:

  • HHV-8 is a significant oncogenic virus with a broad spectrum of hematologic and immunologic impact.
  • Multidisciplinary expert review is essential for accurate diagnosis and effective management.
  • Further research is needed to optimize therapeutic interventions for HHV-8 related diseases.