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Update on noninfectious uveitis in children and its treatment

Ilaria Maccora1, Ethan S Sen2, Athimalaipet V Ramanan3

  • 1Pediatric Rheumatology Unit, A. Meyer Children's University Hospital, University of Florence School of Human Health Science, Florence, Italy.

Current Opinion in Rheumatology
|July 18, 2020
PubMed

Insights

Recent research highlights novel biomarkers and genetic factors for childhood noninfectious uveitis. Advances in biologic therapies offer new hope for treatment-resistant cases, improving outcomes for this sight-threatening condition.

Area of Science:

  • Ophthalmology
  • Pediatrics
  • Immunology

Background:

  • Childhood noninfectious uveitis is a significant cause of vision loss in children.
  • Early identification of risk factors and biomarkers is crucial for effective management.
  • Conventional treatments may be insufficient for some patients, necessitating novel therapeutic approaches.

Purpose of the Study:

  • To review recent literature on risk factors, biomarkers, and treatments for pediatric noninfectious uveitis.
  • To provide an overview of advancements that can inform future screening, monitoring, and therapeutic strategies.
  • To discuss the impact of new biologic therapies and comprehensive outcome measures.

Main Methods:

  • Literature review of recently published articles.
  • Synthesis of findings on genetic markers, serum, aqueous humor, and tear biomarkers.
  • Analysis of clinical factors and outcomes from key trials (SYCAMORE, ADJUVITE, APTITUDE).

Main Results:

  • Identification of numerous genetic and clinical risk factors associated with childhood noninfectious uveitis.
  • Advances in biologic therapies, including adalimumab and tocilizumab, show promise for refractory cases.
  • Emphasis on comprehensive outcome measures for standardized patient assessment.

Conclusions:

  • Novel biomarkers and risk factors aid in tailoring screening and monitoring for pediatric noninfectious uveitis.
  • Biologic therapies are transforming outcomes for patients unresponsive to traditional treatments.
  • Further understanding of disease pathogenesis is essential for optimizing targeted therapies and improving patient care.
Abstract

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