Related Experiment Video
Updated: Dec 14, 2025

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Orthopedic manifestation as the presenting symptom of acute lymphoblastic leukemia
Amrath Raj B K1, Kumar Amerendra Singh2, Hitesh Shah1
1Department of Orthopaedics, Kasturba Hospital, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.
Introduction:
The diagnosis of Acute lymphoblastic leukemia (ALL) is delayed due to vague presentation and normal hematological investigations.
Objective:
The objectives were to identify the frequency of ALL cases presented to the orthopedic department and with normal hematological investigations.
Material And Methods:
250 consecutive ALL cases were retrospectively evaluated to identify cases with musculoskeletal manifestations, and laboratory investigations.
Results:
Twenty-two patients (4- vertebral compression fractures, 12- joint pain, 6- bone pain), presented primarily to the orthopedic department. Six patients had a normal peripheral smear.
Conclusion:
The primary physician should maintain a high index of suspicion despite a normal peripheral smear.
Related Concept Videos
Disorders of Leukocytes
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Chronic Kidney Disease II: Clinical Manifestations
Pulmonary Tuberculosis III
The first classification is based on the development of the disease, and it includes the following categories:
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
Primary Lymphoid Organs
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Cells of the Adaptive Immune Response

