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Relationship between Left Ventricular Outflow Tract Pressure Gradient and Hemoglobin in Patients with Hypertrophic

Yangyi Lin1, Lisha Yu2, Fangfei Liu3

  • 1Department of Cardiology, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences.

Acta Cardiologica Sinica
|July 18, 2020
PubMed

Insights

Lower hemoglobin levels are linked to increased left ventricular outflow tract obstruction in hypertrophic cardiomyopathy patients. This finding suggests hemoglobin can help predict obstruction severity in hypertrophic obstructive cardiomyopathy.

Area of Science:

  • Cardiology
  • Internal Medicine
  • Hematology

Background:

  • Anemia association with left ventricular outflow tract obstruction in hypertrophic obstructive cardiomyopathy (HOCM) is suggested but lacks large-scale clinical validation.
  • Hypertrophic cardiomyopathy (HCM) is a condition affecting the heart muscle, potentially leading to obstruction of blood flow out of the left ventricle.

Purpose of the Study:

  • To investigate the relationship between left ventricular outflow tract (LVOT) pressure gradient and hemoglobin levels in patients diagnosed with hypertrophic cardiomyopathy (HCM).
  • To determine if hemoglobin levels can serve as a predictive marker for LVOT obstruction in HCM patients.

Main Methods:

  • Retrospective analysis of demographic, laboratory, and echocardiography data from 310 HCM patients (July 2014 - March 2019).
  • Patients were categorized into HOCM and non-HOCM groups for comparative analysis.
  • Statistical methods included correlation analysis and receiver operating characteristic (ROC) curve analysis to assess predictive value.

Main Results:

  • Patients with HOCM exhibited significantly lower hemoglobin levels (112.2 g/L) compared to non-HOCM patients (132.9 g/L).
  • A significant inverse correlation was observed between hemoglobin levels and LVOT pressure gradient in both males (r = -0.568) and females (r = -0.589).
  • ROC analysis identified specific hemoglobin cut-off values (128 g/L for males, 125 g/L for females) with notable sensitivity and specificity for predicting HOCM.

Conclusions:

  • Hemoglobin level is inversely proportional to the LVOT pressure gradient in HCM patients.
  • Hemoglobin levels demonstrate predictive value for identifying outflow tract obstruction in patients with hypertrophic cardiomyopathy.
  • These findings support the use of hemoglobin as a potential biomarker for assessing the severity of LVOT obstruction in HCM.
Abstract

Keywords:
Bernoulli equationContinuity equationDynamic obstructionHemolytic anemiaLeft ventricular outflow tract pressure gradient

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