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Appendicitis-I: Introduction01:22

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Chronic Bowel Disorders: Introduction01:17

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Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
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Related Experiment Video

Updated: Dec 14, 2025

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
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Appendiceal sarcoidosis presenting as acute appendicitis.

Venkata Satish Pendela1, Anisleidys Munoz1, Mamta Chhabria1

  • 1Department of Internal Medicine, Rochester General HospitalRochesterNew York.

Proceedings (Baylor University. Medical Center)
|July 18, 2020
PubMed
Summary

Appendiceal sarcoidosis, a rare cause of abdominal pain, was diagnosed in a patient with systemic sarcoidosis. This case highlights the need to consider rare gastrointestinal manifestations in patients with sarcoidosis.

Keywords:
Acute appendicitisappendiceal neoplasmappendiceal sarcoidosisgastrointestinal sarcoidosis

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Area of Science:

  • Gastroenterology
  • Immunology
  • Pathology

Background:

  • Sarcoidosis is a multisystem inflammatory disease.
  • Gastrointestinal involvement is common, with the stomach being most frequently affected.
  • Appendiceal sarcoidosis is an exceptionally rare presentation.

Observation:

  • A 49-year-old woman presented with abdominal pain, initially suspected as acute appendicitis.
  • Ultrasound findings were consistent with acute appendicitis, leading to laparoscopic appendectomy.
  • Histopathological examination of the appendix revealed nonnecrotizing granulomas.

Findings:

  • The patient was diagnosed with systemic sarcoidosis based on noncaseating granulomas found in mediastinal lymph nodes.
  • Post-operative treatment included steroid therapy and mycophenolate mofetil.
  • Appendiceal sarcoidosis was confirmed as the cause of her symptoms.

Implications:

  • This case underscores the importance of including appendiceal sarcoidosis in the differential diagnosis for patients with systemic sarcoidosis presenting with acute abdominal symptoms.
  • Recognizing rare gastrointestinal manifestations of sarcoidosis is crucial for accurate diagnosis and management.
  • Early identification can prevent unnecessary procedures and guide appropriate immunosuppressive therapy.