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Updated: Jul 15, 2026

Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke
Published on: February 12, 2015
Comment on Saber et al. (2019), "Commentary: the chronic inhalation study in rats for assessing lung cancer risk may
Kevin E Driscoll1, Paul A Borm2,3, Ishrat Chaudhuri4
1Ernest Mario School of Pharmacy, Rutgers, New Brunswick, NY, 07046, USA. kevinedriscoll1@gmail.com.
Abstract:
In their Commentary Saber et al. (Part Fibre Toxicol 16: 44, 2019) argue that chronic inhalation studies in rats can be used for assessing the lung cancer risk of insoluble nanomaterials. The authors make several significant errors in their interpretation and representation of the underlying science. In this Letter to the Editor we discuss these inaccuracies to correct the scientific record. When the science is recounted accurately it does not support Saber et al's statements and conclusions.
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