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Into the Unknown: A Chemical Biology Approach Provides Mechanistic Insight into HCV Entry
Fang Chen1, Luke L Lairson2, Mansun Law1
1Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Cell Chemical Biology
|July 18, 2020
Abstract:
In this issue of Cell Chemical Biology, Hu et al. (2020) demonstrate that chlorcyclizine blocks HCV fusion by targeting the putative fusion peptide on the viral envelope glycoprotein E1. The study provides new insights into the viral fusion machinery, presenting an opportunity to study novel antivirals against HCV.
