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Related Concept Videos

Mechanisms of Membrane Domain Formation00:59

Mechanisms of Membrane Domain Formation

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Different physical properties of lipids and proteins allow them to localize and form distinct islands or domains in the membrane. Some membrane domains are formed due to protein-protein interactions, whereas others are formed due to the presence of specific lipids such as sphingolipids and sterols—for example, large proteins, such as bacteriorhodopsin, aggregate and create distinct domains.
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A key characteristic of life is the ability to separate the external environment from the internal space. To do this, cells have evolved semi-permeable membranes that regulate the passage of biological molecules. Additionally, the cell membrane defines a cell’s shape and interactions with the external environment. Eukaryotic cell membranes also serve to compartmentalize the internal space into organelles, including the endomembrane structures of the nucleus, endoplasmic reticulum and...
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A cell's plasma membrane demarcates the cell's borders and determines the nature of its interaction with the environment. Cells exclude certain substances, take in others, and excrete some others in controlled quantities. The plasma membrane must be flexible to allow certain cells, such as red and white blood cells, to change their shape while passing through narrow capillaries. These are the more obvious plasma membrane functions. In addition, the plasma membrane's surface carries...
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A tissue membrane is a thin layer of cells that covers the outside of the body, the organs, internal passageways that lead to the exterior of the body, and the lining of the moveable joint cavities. There are two basic types of tissue membranes— connective tissue and epithelial membranes.
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Scientists identified the plasma membrane in the 1890s and its principal chemical components (lipids and proteins) by 1915. The model for plasma membrane structure, proposed in 1935 by Hugh Davson and James Danielli, was the first model to be widely accepted in the scientific community. The model was based on the plasma membrane's "railroad track" appearance in early electron micrographs. Davson and Danielli theorized that the plasma membrane's structure resembled a sandwich...
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The protrusion of the cell surface is an initial step for several cellular processes, including cell migration, phagocytosis, and neurite outgrowth. These membrane protrusions are a result of cytoskeletal rearrangement. The most  widely observed cell protrusions include lamellipodia, pseudopodia, filopodia, microvilli, invadopodia, and podosomes. These protrusions can be of two types — static or dynamic.
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Related Experiment Video

Updated: Dec 14, 2025

Automated Lipid Bilayer Membrane Formation Using a Polydimethylsiloxane Thin Film
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Solid-state membranes formed on natural menisci.

Zach Walker1, Tanner Wells1, Kalliyan Lay1

  • 1Department of Electrical and Computer Engineering, Brigham Young University, Provo, UT, United States of America.

Nanotechnology
|July 18, 2020
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel method for fabricating robust, nanoscale solid-state membranes. This technique utilizes the natural shape of a liquid meniscus as a template, enabling the creation of ultra-thin membranes for advanced applications.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Chemical Engineering

Background:

  • Fabricating robust, nanoscale solid-state membranes is crucial for various advanced applications.
  • Existing methods often face challenges in achieving large areas and precise thickness control.

Purpose of the Study:

  • To present a novel, template-assisted method for creating robust, nanoscale solid-state membranes.
  • To demonstrate the fabrication of large-area, ultra-thin suspended membranes with controlled thickness.

Main Methods:

  • Utilizing the natural concave shape of a liquid meniscus within a silicon channel as a template.
  • Employing spontaneous capillary action to introduce a photoresist polymer into etched channels.
  • Covering the meniscus with a thin chemical vapor deposited membrane.
  • Removing the polymer via sacrificial etching to yield a suspended membrane.

Main Results:

  • Successfully fabricated robust, nanoscale solid-state membranes.
  • Demonstrated the ability to create membranes as large as 20 μm by 9 mm.
  • Achieved membrane thicknesses as low as 50 nm.
  • The method relies on the self-assembly properties of liquids and sacrificial etching.

Conclusions:

  • The presented method offers a scalable and effective approach for fabricating high-quality nanoscale membranes.
  • This technique leverages natural phenomena for precise templating, enabling the production of large-area, ultra-thin suspended structures.
  • The developed membranes hold potential for applications in microelectronics, sensors, and filtration.