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Related Experiment Video

Updated: Dec 14, 2025

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
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Accelerated single cell seeding in relapsed multiple myeloma.

Heather J Landau1,2, Venkata Yellapantula3,4, Benjamin T Diamond4

  • 1Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Nature Communications
|July 19, 2020
PubMed
Summary
This summary is machine-generated.

Cancer cells in multiple myeloma (MM) spread throughout the body. Our study reveals that chemotherapy can create a unique genomic barcode, showing MM spreads faster at relapse due to a single surviving cell after treatment.

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Area of Science:

  • Oncology
  • Genomics
  • Cancer Evolution

Background:

  • Multiple myeloma (MM) progression involves cancer cell dissemination to various anatomical sites.
  • Understanding the evolutionary dynamics of MM is crucial for effective treatment strategies.

Purpose of the Study:

  • To characterize the evolutionary process of cancer cell seeding in multiple myeloma.
  • To investigate the impact of chemotherapy on MM evolution and dissemination.

Main Methods:

  • Whole genome sequencing of 25 autopsy samples from 4 relapsed MM patients.
  • Whole exome sequencing of 125 samples from 51 MM patients.
  • Mutational signatures analysis to identify chemotherapy-induced mutations.

Main Results:

  • Cytotoxic agents introduce unique mutations in surviving cancer cells, forming a single-cell genomic barcode.
  • This barcode links chemotherapy exposure to specific time windows.
  • Systemic seeding of MM is accelerated at relapse, driven by the expansion of a single cell post-treatment.

Conclusions:

  • Chemotherapy can generate identifiable genomic signatures in individual cancer cells.
  • Relapsed MM dissemination is accelerated and linked to the clonal expansion of a single cell after high-dose melphalan and stem cell transplant.