N⁶-methyladenosine as a Novel Regulator of Brain Physiology and Diseases

N⁶-methyladenosine (m⁶A) is identified as the most widespread and abundant internal chemical modification of RNA in eukaryotes. A series of proteins including methyltransferases (also known as "writers"), demethylases (also known as "erasers"), and m⁶A-binding proteins (also known as "readers") were indicated to participate in the m⁶A methylation. m⁶A has emerged as a regulator of various cellular, developmental, and disease processes. Notably, there is highest abundance of m⁶A methylation in brain than in other organs, which indicates that m⁶A plays an essential role in brain functions. Here, we describe the general features, mechanisms, and functions of m⁶A in the brain, and discuss the emerging roles of m⁶A in brain physiology and diseases.