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Immunohistochemical study of lichen planus.
Journal of Clinical Pathology
|June 1, 1977
Summary
Immunoglobulin M (IgM) and Immunoglobulin G (IgG) deposits were found in lichen planus skin biopsies using the PAP technique. These findings offer insights into the immunological aspects of this inflammatory skin condition.
Area of Science:
- Immunodermatology
- Histopathology
Background:
- Lichen planus is an inflammatory condition affecting skin and mucous membranes.
- The role of immunoglobulins in lichen planus pathogenesis requires further elucidation.
Purpose of the Study:
- To investigate the distribution of IgM and IgG in lichen planus using the unlabeled antibody-enzyme PAP technique.
- To compare immunoglobulin deposition in lichen planus with non-specific inflammation.
Main Methods:
- The unlabeled antibody-enzyme (PAP) technique was employed on routine paraffin-embedded skin sections.
- Twenty cases of lichen planus and five cases of non-specific inflammation were analyzed.
Main Results:
- Immunoglobulin deposits (IgM and IgG) were observed in epithelial cells, colloid bodies, dermo-epidermal junctions, and inflammatory cells in lichen planus.
- IgM was positive in all lichen planus cases, while IgG was positive in 8 out of 13 cases.
- Peripheral migrating epidermal cells in lichen planus were predominantly negative for immunoglobulins.
Conclusions:
- The PAP technique is effective for detecting immunoglobulin deposition in skin biopsies.
- The presence and distribution of IgM and IgG suggest their involvement in the immunological response in lichen planus.